Allergoids Allergen Immunotherapy
Allergoids offer an alternative to native allergen extract vaccines with a number of benefits. Scientific studies have shown that allergoids can offer a reduced risk of serious side effects1 when compared to traditional native immunotherapy vaccines with equivalent efficacy.2,3
- Glutaraldehyde-polymerised standardised allergoids
- Achieve full maintenance dose within 1-3 weeks
- Reduced binding to specific IgE, hence it is less allergenic than the native extract1
- Lower Capacity to react with IgE4
- Lowered Basophils/Mast Cell activation5,6
- Improved tolerability7,8
References:
1. Lee et al. Modified antigens in the treatment of allergic disease. Year Immunol. 1986;2:338-50
2. Kohlmoos, et al. Specific Immunotherapy with a Polymerized Tree Pollen Allergen Extract Is Effective and Safe J Allerg Clin Immunol 2009;123(2):S61
3. Klimek et al. A high polymerized grass pollen extract is efficacious and safe in a randomized double-blind, placebo-controlled study using a novel up-dosing cluster-protocol. Allergy 69 (2014) 1629-1638.
4. Manzano et al. Structural studies of novel glycoconjugates from polymerized allergens (allergoids) and mannans as allergy vaccines. Glycoconjugate J.(2015) DOI 10.1007/s10719-015-9640-4
5. Mothes N, Heinzkill M, Drachenberg KJ, Sperr WR, Krauth MT, Majlesi Y, et al. Allergen-specific immunotherapy with a monophosphoryl lipid A-adjuvanted vaccine: reduced seasonally boosted immunoglobulin E production and inhibition of basophil histamine release by therapy-induced blocking antibodies. Clinical & Experimental Allergy 2003; 33(9):1198-1208.
6. Grammer LC, Shaughnessy MA, Patterson R. Modified forms of allergen immunotherapy. J Allergy Clin Immunol 1985; 76:397-401.
7. Subiza et al. Subcutaneous immunotherapy: safety of modified and unmodified allergen extracts. Allergy 65 (Suppl. 92): 564 (2010)
8. Uhlig et al. Safety and efficacy or specific immunotherapy with polymerized cat allergen extracts in patients with allergy to cat dander. Allergy 2009;64 Supplement 90:460